Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer
LC impairs BBB integrity via paraneoplastic effects, with subtype heterogeneity: ADC (high perfusion/leakage) involves global white matter; SCLC (prominent interstitial disruption) affects mainly deep regions. Findings aid LC brain metastasis risk stratification and neuroprotective strategies.
Authors
- Jun Zhou (ORCID: https://orcid.org/0000-0001-9288-6299)
- Ruipeng Liang
- Hongying Liu (ORCID: https://orcid.org/0000-0003-1676-1624)
- Chunrong Wu
- Xiufu Zhang
- Jian Zeng
- Zhengzhen Li
- Yi Wang
- Haotian Wang
- Yonglong Li
Institutions
- Jiangjin Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fonc.2026.1717244
- Primary Topic
- MRI in cancer diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00