D-Allulose Reduces Weight More Persistently than Oral Semaglutide While Both Equally Elevate Grip Strength in Diet-Induced Obese Mice
D-Allulose and O-Sema equally elicit weight reduction possibly via the central nervous route including ARH anorexigenic neuron activation. The weight loss is rebounded with O-Sema, while it is maintained with D-Allulose possibly via combined vagal afferent and central nervous routes including ARH orexigenic neuron inhibition. Their optimal use potentially provides precise control of obesity and related disorders.
Authors
- Shin Tsunekawa (ORCID: https://orcid.org/0000-0002-9890-5777)
- Yermek Rakhat (ORCID: https://orcid.org/0000-0003-1233-0392)
- Yutaka Seino
- Seiya Banno (ORCID: https://orcid.org/0009-0000-7345-7974)
- Daisuke Yabe
- Dauren Zhantleu (ORCID: https://orcid.org/0000-0003-4102-7229)
- Yusaku Iwasaki
- Toshihiko Yada
Institutions
- Fujita Health University (JP)
- Kyoto Prefectural University (JP)
- Kyoto University (JP)
- Kansai Electric Power (Japan) (JP)
- Kyoto Prefectural University of Medicine (JP)
- Integrative Medicine Institute (US)
- Gifu University (JP)
Publication Details
- Journal
- Nutrients
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3390/nu18040707
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00