m6A-mediated stabilization of Bhlhe22 suppresses osteogenesis in osteoporosis by activating the PI3K-AKT-GSK3β signaling axis
m<sup>6</sup>A modification stabilizes Bhlhe22 mRNA, leading to its overexpression in OP. Elevated BHLHE22 protein suppresses BMSC osteogenesis by transcriptionally activating Pik3r3 and the PI3K-AKT-GSK3β signaling axis. Targeting the m<sup>6</sup>A-Bhlhe22-PI3K axis represents a promising therapeutic strategy for osteoporosis.
Authors
- Qianke Tao (ORCID: https://orcid.org/0000-0002-9825-0985)
- Fangzhi Lou
- Qilian Ye
- Dan Tan
- Jingxiang Li
- Jingang Xiao
- Xiaobing Li
- Xuemei Long
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1186/s13287-026-04935-4
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00