Subcortical microstructural impairment in amyotrophic lateral sclerosis: clinical correlates of neurite orientation dispersion and density imaging (NODDI) changes
These findings suggest subtle and predominantly exploratory associations between DGM microstructural properties and clinical measures in ALS. NODDI derived metrics, particularly ODI and NDI, may provide sensitive indices of subcortical microstructural variation, warranting further investigation in larger cohorts.
Authors
- Francesca Trojsi (ORCID: https://orcid.org/0000-0002-3790-8018)
- Fabrizio Canale
- Giuseppina Caiazzo (ORCID: https://orcid.org/0000-0001-7403-4172)
- Minoo Sharbafshaaer (ORCID: https://orcid.org/0000-0001-9887-5304)
- Maria Agnese Pirozzi (ORCID: https://orcid.org/0000-0002-4632-3513)
- Fabrizio Esposito (ORCID: https://orcid.org/0000-0002-5099-9786)
- Antonio Russo (ORCID: https://orcid.org/0000-0002-0601-0475)
- Marcello Silvestro (ORCID: https://orcid.org/0009-0002-3288-1685)
- Alessandro Tessitore
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-13
- DOI
- https://doi.org/10.3389/fnins.2026.1757470
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute