Integrated Histology and Molecular Profiling of Postmortem Human Auditory and Vestibular Organs via a Poly (Methyl Methacrylate)-Based Workflow
This rPMMA-based workflow combines gold-standard histomorphology with full compatibility for advanced molecular analyses. With dramatically reduced time and cost, it offers a new benchmark for integrated, spatially resolved studies of human hearing and balance pathologies.
Authors
- Sabina Wunderlin
- Anbuselvan Dharmarajan
- Anja Kipar (ORCID: https://orcid.org/0000-0001-7289-3459)
- Susanne Kreutzer (ORCID: https://orcid.org/0000-0001-6286-534X)
- Christof Röösli (ORCID: https://orcid.org/0000-0002-2425-9792)
- Andreas H. Eckhard (ORCID: https://orcid.org/0000-0002-4921-6043)
- Nora M. Weiss (ORCID: https://orcid.org/0000-0002-0645-3591)
- Brigitte von Rechenberg (ORCID: https://orcid.org/0000-0002-3836-6812)
- Mengyu Zhu (ORCID: https://orcid.org/0000-0003-2318-3666)
- Steven Senese
- Brock Peyton
- Jennifer T. O’Malley
- Alison Brown
- Sami S. Amr
- Jacqueline Neubauer
- Venus Kallupurackal
- Zsuzsanna Varga
- David Bächinger
- Adrian Dalbert
- Heiko Richter
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- University of Zurich (CH)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
- Medizinisches Laserzentrum Lübeck (Germany) (DE)
- University of Rostock (DE)
- Mass General Brigham (US)
- Technical University of Munich (DE)
Publication Details
- Journal
- Journal of the Association for Research in Otolaryngology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1007/s10162-026-01032-4
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eberhard Karls Universität Tübingen