Outcomes of once daily and twice daily accelerated partial breast irradiation regimens in hormone receptor positive breast cancer: a single institution experience
Both regimens-38.5 Gy in 10 twice-daily fractions and 28.5 Gy in 5 once-daily fractions-delivered using 3D-conformal technique in the prone position yielded excellent 3-year outcomes. Nonetheless, the 28.5 Gy regimen demonstrated a lower incidence of acute and late toxicity and may be preferable in this patient population given its lower skin toxicity and increased convenience. Longer follow-up is warranted to confirm these findings.
Authors
- Rebekah Young
- Jacob Eckstein
- Mariella Mestres-Villanueva (ORCID: https://orcid.org/0000-0002-7130-1404)
- T.Y. Andraos
- Sasha Beyer (ORCID: https://orcid.org/0000-0001-5651-6581)
- Tanun Jitwatcharakomol
- Pavnesh Kumar
- Sierra Daniel
- Y. Gokun
- E. Cochran
- J. White
- J. G. Bazan
- S. Jhawar
- Erin H. Healy
Institutions
- City Of Hope National Medical Center (US)
- Siriraj Hospital (TH)
- University of California, Irvine (US)
- Mahidol University (TH)
- The Ohio State University Wexner Medical Center (US)
- University of California, Irvine Medical Center (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1186/s13058-026-02243-6
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00