Adipose-derived stem cell-conditioned medium mitigates ischemia-induced neuronal injury via the JAK1/STAT3 signaling pathway
The neuroprotective effects of ADSC-CM are mechanistically linked to the activation of the JAK1/STAT3 pathway, which mitigates ischemic damage by promoting neuronal salvage, neurovascular regeneration, synaptic plasticity, and metabolic recovery, thereby enhancing neurological functional recovery after stroke.
Authors
- Mouwei Zheng
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Huan Huang (ORCID: https://orcid.org/0000-0002-0804-9541)
- Yongxing Lai
- Yixian Zhang
- Nan Liu
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Union Hospital (US)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fncel.2026.1744887
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province