Bloodstream infections and Blood-Brain barrier Permeability: An observational cohort study
Our findings suggest that BSI are associated with acute, inflammation-mediated brain injury. However, cognitive dysfunction, particularly in the domain of attention, is temporary and not associated with changes in BBB permeability or microglial activation at convalescence. Given persistent mood dysfunction and elevated biomarkers of neuronal injury longitudinal study is warranted to determine long-term sequelae of BSI and other severe infections.
Authors
- Nicholas G. Dowell (ORCID: https://orcid.org/0000-0002-1978-4779)
- Itamar Ronen (ORCID: https://orcid.org/0000-0002-6872-4895)
- Eva Periche-Tomas (ORCID: https://orcid.org/0000-0002-3909-9875)
- Sam Loveless
- Neil A. Harrison
- Jonathan Underwood
- John Evans
- Mara Cercignani
- Kate Davies
- James E. McLaren
Institutions
- Brighton and Sussex Medical School (GB)
- Cardiff and Vale University Health Board (GB)
- University of Sussex (GB)
- University of Oxford (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1016/j.bbi.2026.106518
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council