Sleep deprivation silently undermines immunity

Sleep plays a critical role in maintaining overall health, immune function, cognitive performance, and emotional stability. However, recent societal changes have contributed to a significant decline in both the quality and duration of sleep, resulting in an increase in sleep disorders, particularly sleep deprivation (SD). SD negatively impacts immune responses, promotes inflammation, and heightens vulnerability to various diseases. Despite the growing concerns, comprehensive studies exploring the full extent of SD's impact on the immune system remain limited. This review aims to investigate the complex relationship between SD and immune function, focusing on the mechanisms behind these effects. The ultimate objective is to enhance our understanding of how SD influences immune health and to inform future research aimed at developing targeted therapeutic interventions.

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Publication Details

Journal
International Journal of Surgery
Published
2025-12-02
DOI
https://doi.org/10.1097/js9.0000000000004071
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Sleep deprivation silently undermines immunity

Yanan Sun, Shuang Li, Chun Feng, Mao Zhangyan
International Journal of Surgery
Sleep and related disorders
article

Sleep deprivation silently undermines immunity

Yanan Sun, Shuang Li, Chun Feng, Mao Zhangyan
article en

Abstract

Sleep plays a critical role in maintaining overall health, immune function, cognitive performance, and emotional stability. However, recent societal changes have contributed to a significant decline in both the quality and duration of sleep, resulting in an increase in sleep disorders, particularly sleep deprivation (SD). SD negatively impacts immune responses, promotes inflammation, and heightens vulnerability to various diseases. Despite the growing concerns, comprehensive studies exploring the full extent of SD's impact on the immune system remain limited. This review aims to investigate the complex relationship between SD and immune function, focusing on the mechanisms behind these effects. The ultimate objective is to enhance our understanding of how SD influences immune health and to inform future research aimed at developing targeted therapeutic interventions.

International Journal of SurgeryVol. 112(2)
Union Hospital (HK), Wuhan Children's Hospital (CN), Huazhong University of Science and Technology (CN)
Openalex Percentile: Top 20%
Sleep and related disorders
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