Sleep deprivation silently undermines immunity
Sleep plays a critical role in maintaining overall health, immune function, cognitive performance, and emotional stability. However, recent societal changes have contributed to a significant decline in both the quality and duration of sleep, resulting in an increase in sleep disorders, particularly sleep deprivation (SD). SD negatively impacts immune responses, promotes inflammation, and heightens vulnerability to various diseases. Despite the growing concerns, comprehensive studies exploring the full extent of SD's impact on the immune system remain limited. This review aims to investigate the complex relationship between SD and immune function, focusing on the mechanisms behind these effects. The ultimate objective is to enhance our understanding of how SD influences immune health and to inform future research aimed at developing targeted therapeutic interventions.
Authors
- Yanan Sun (ORCID: https://orcid.org/0000-0003-4940-3743)
- Shuang Li (ORCID: https://orcid.org/0000-0002-9193-0320)
- Chun Feng
- Mao Zhangyan
Institutions
- Union Hospital (HK)
- Wuhan Children's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-02
- DOI
- https://doi.org/10.1097/js9.0000000000004071
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00