Lactobacillus rhamnosus confers protection against enteropathogenic bacteria by enhancing mucosal immunity and epithelial barrier function
CIQ249 enhances mucosal defense against enteropathogenic bacteria through a dual mechanism-strengthening the epithelial barrier and activating a coordinated DC-Tfh-IgA immune axis. These findings provide a multi-level mechanistic basis for its application as a microecological agent against intestinal infections.
Authors
- Jiayi Xiang
- Yan Xu (ORCID: https://orcid.org/0000-0003-0379-8866)
- Yong Li (ORCID: https://orcid.org/0000-0003-4038-0493)
- Yu Han (ORCID: https://orcid.org/0000-0002-5415-7535)
- Yi Liu (ORCID: https://orcid.org/0000-0002-1058-0382)
- Kai Yan (ORCID: https://orcid.org/0009-0005-4430-7412)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- X D Gao
- Jiangfei Zhou
- Yueming Guan
Institutions
- Zhejiang A & F University (CN)
- Sun Yat-sen University (CN)
- Jilin Agricultural University (CN)
- Zhongkai University of Agriculture and Engineering (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fcimb.2026.1769889
- Primary Topic
- Probiotics and Fermented Foods
- Type
- article
- Field-Weighted Citation Impact
- 0.00