Regioselective Synthesis of 4,4′-Bipyrazoles via Palladium-Catalyzed Cyclizative Dimerization of Alkynic Hydrazones
Palladium-catalyzed cyclizative dimerization of alkynic hydrazones afforded 4,4'-bipyrazoles. The desired dimerization reaction proceeded efficiently by using the Pd(tfa)<sub>2</sub>/DPPF catalyst. Several functional groups were tolerated under the reaction conditions, and various bipyrazoles, including fully substituted bipyrazoles, were successfully synthesized.
Authors
- Shoko Kikkawa (ORCID: https://orcid.org/0000-0002-9390-5671)
- Keisuke Takahashi (ORCID: https://orcid.org/0000-0002-1438-9091)
- Keisuke Kato (ORCID: https://orcid.org/0000-0003-4408-4181)
- Taichi Kusakabe
- Isao Azumaya (ORCID: https://orcid.org/0000-0002-6651-2768)
- Chizuru Torii
- Handong Wang
Institutions
- Toho University (JP)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1021/acs.joc.6c00022
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00