Microvesicles in stored human whole blood increase thrombin generation via phosphatidylserine
Whole blood storage results in increased thrombin generation potential over time. This has previously been viewed as beneficial but could be detrimental when unchecked. These data suggest that changes in thrombin generation are due in part to phosphatidylserine expression on microvesicles produced during storage. These data highlight the need for further studies investigating the use of stored whole blood.
Authors
- Lindsey J Wattley
- Timothy A. Pritts (ORCID: https://orcid.org/0000-0003-2495-3255)
- Michael D. Goodman (ORCID: https://orcid.org/0000-0001-7218-4855)
- Ryan C Chae (ORCID: https://orcid.org/0000-0002-2045-0303)
- Rebecca H. Schuster
Institutions
- RELX Group (Netherlands) (NL)
- University of Cincinnati (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2026-01-20
- DOI
- https://doi.org/10.1097/ta.0000000000004834
- Primary Topic
- Blood Coagulation and Thrombosis Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00