Maternal inflammation and oxidative stress during pregnancy in relation to early childhood neurodevelopment

These findings suggest that gestational inflammation and oxidative stress may adversely affect early neurodevelopment, with associations potentially modified by gestational timing, child age, and child sex. Future research should prioritize investigating the mediating roles of inflammation and oxidative stress in the relationship between multiple stressors during pregnancy and child neurodevelopment.

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Publication Details

Journal
Brain Behavior and Immunity
Published
2026-02-23
DOI
https://doi.org/10.1016/j.bbi.2026.106514
Primary Topic
Tryptophan and brain disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

Maternal inflammation and oxidative stress during pregnancy in relation to early childhood neurodevelopment

Sung Kyun Park, Seonyoung Park, Zaira Rosario, Gredia Huerta Montañez et al.
Brain Behavior and Immunity
Tryptophan and brain disorders
article

Maternal inflammation and oxidative stress during pregnancy in relation to early childhood neurodevelopment

Sung Kyun Park, Seonyoung Park, Zaira Rosario, Gredia Huerta Montañez, Ryan C. Lewis, Carmen M. Vélez Vega, Wei Hao, Deborah J. Watkins, Akram Alshawabkeh
article en

Abstract

These findings suggest that gestational inflammation and oxidative stress may adversely affect early neurodevelopment, with associations potentially modified by gestational timing, child age, and child sex. Future research should prioritize investigating the mediating roles of inflammation and oxidative stress in the relationship between multiple stressors during pregnancy and child neurodevelopment.

Brain Behavior and ImmunityVol. 135
Northeastern University (US), University of Puerto Rico, Medical Sciences Campus (PR), University of Georgia (US), University of Michigan (US), Yale University (US)
No poverty
Openalex Percentile: Top 51%
Tryptophan and brain disorders
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