Cerebral ischemia-reperfusion induced cardiac injury in rats: involvement of oxidative stress, apoptosis, TLR4, nF-κB and HSP70: the rescue effect of losartan
In all, cerebral IR increased cardiac oxidative stress and apoptosis which positively correlates with TLR4/NF-κB pathway. Additionally, losartan can be considered as a potential target for preventing cardiac injury following stroke.
Authors
- Hamid Sorayya
- Roya NADERI
- Yasaman Shakouri
Institutions
- Urmia University (IR)
- Cellular Research (United States) (US)
- Urmia University of Medical Sciences (IR)
Publication Details
- Journal
- Biomarkers
- Published
- 2026-03-04
- DOI
- https://doi.org/10.1080/1354750x.2026.2634890
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00