Comparative Strategies to Overcome Diuretic Resistance in Heart Failure
In HF with diuretic resistance, sodium-glucose cotransporter 2 inhibitors may lower rehospitalization with a favorable renal profile, whereas nephron-segment add-ons enhance short-term decongestion but warrant AKI/electrolyte monitoring; rankings are exploratory, and choices should emphasize absolute effects and 95% CIs.
Authors
- Lucas C. Godoy (ORCID: https://orcid.org/0000-0001-6171-1269)
- Darshan H. Brahmbhatt (ORCID: https://orcid.org/0000-0003-3440-0523)
- Adriana C. Luk
- Filio Billia
- Michael McDonald
- Edimar A. Bocchi
- Ivna GCV. Lima
- Jairo T. Nunes
Institutions
- Mount Sinai Hospital (CA)
- University of Toronto (CA)
- Ted Rogers Centre for Heart Research (CA)
- Sinai Health System (CA)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Hospital Sírio-Libanês (BR)
Publication Details
- Journal
- JACC Advances
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1016/j.jacadv.2026.102617
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00