Microsecond Dynamics of Fc–CD16a Recognition: Impact of Mutations, Core Fucosylation, and Fc Asymmetry
Altogether, these findings provide a quantitative framework for how targeted mutations and fucose modifications remodel Fc-CD16a interactions, offering insights for the rational design of next-generation therapeutic antibodies.
Authors
- Sébastien Estaran (ORCID: https://orcid.org/0009-0008-2901-5464)
- Alain Chavanieu (ORCID: https://orcid.org/0000-0002-0512-5115)
- Bernard Hehlen
Institutions
- Centre National de la Recherche Scientifique (FR)
- Laboratoire Charles Coulomb (FR)
- Institut des Biomolécules Max Mousseron (FR)
Publication Details
- Journal
- Antibodies
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3390/antib15010017
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00