Long Non‐Coding <scp>RNA H19</scp> mediates <scp>STAT3</scp> dependent activation of keratinocytes and fibroblasts in Systemic Sclerosis skin
This study shows that lncRNA H19 is a key mediator of STAT3 induced changes in fibrotic activation of fibroblast and keratinocytes in SSc skin and could be considered a promising therapeutic target in tissue fibrosis.
Authors
- R. Ross
- Christopher W. Wasson (ORCID: https://orcid.org/0000-0001-6558-4738)
- Begoña Caballero-Ruiz (ORCID: https://orcid.org/0000-0001-5278-5573)
- Francesco Del Galdo
Institutions
- University of Leeds (GB)
- Chapel Allerton Hospital (GB)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1002/art.70104
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00