Improved Detection of Myositis‐Specific Autoantibodies Using Luciferase Immunoprecipitation Systems Assay: Comparison with Line Blot and Conventional Immunoprecipitation
LIPS provides quantitative discrimination, strong concordance with IP, and improved performance compared with line blot, particularly at low to intermediate titers. By reducing misclassification and complementing antibody-specific thresholds, LIPS has the potential to enhance clinical stratification in myositis patients.
Authors
- Anthony F. Suffredini (ORCID: https://orcid.org/0000-0003-4179-0902)
- Shouguo Gao (ORCID: https://orcid.org/0000-0002-8275-0598)
- Julio Arturo Huapaya (ORCID: https://orcid.org/0000-0001-8093-4855)
- John A. Chiorini (ORCID: https://orcid.org/0000-0003-4919-4056)
- E. J. Robbins
- Peter D. Burbelo
- Xin Tian
- Neha Gupta
- Christopher A Mecoli
- Iago Pinal-Fernandez
- Lisa Christopher-Stine
- Livia Casciola-Rosen
- Andrew Mammen
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- National Institute of Dental and Craniofacial Research (US)
- National Heart, Lung, and Blood Institute (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1002/art.70103
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00