YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m <sup>5</sup> C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis
Our study unveils a novel epitranscriptomic mechanism in which YBX1 drives CoNV by regulating the stability of m5C-modified STAT3 and VEGFA mRNAs, thereby activating the JAK1/STAT3/HIF-1α axis. Inhibition of YBX1 with SII effectively counteracts this pathway, highlighting YBX1 as an attractive candidate for intervention against sight-threatening CoNV.
Authors
- Ying Yan (ORCID: https://orcid.org/0000-0001-8556-7417)
- Yanning Yang (ORCID: https://orcid.org/0009-0004-7514-0128)
- Qian Deng (ORCID: https://orcid.org/0000-0003-0346-7709)
- Yingli Wang
- Jiewen Mao
- Yuelan Gao
- Shanshan Wan
- Lan Ke
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1167/iovs.67.2.42
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00