U-shaped association between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol and risk of cholelithiasis: a cohort study

Our findings suggest that elevated NHHR is significantly associated with an increased risk of incident cholelithiasis, demonstrating a U-shaped relationship with a nadir at approximately 1.84. These results underscore the potential of NHHR as a valuable clinical marker for assessing cholelithiasis risk, guiding individualized intervention strategies, and alleviating both economic burdens and the risk of severe complications.