Molecular targeted therapy in combination with chemotherapy for the treatment of platinum-resistant/refractory ovarian cancer (PROC): a systematic review and network meta-analysis

Bevacizumab-based combinations demonstrate consistent benefits across multiple regimens for PROC. Paclitaxel + bevacizumab emerges as the optimal balance of efficacy and safety. Topotecan + sorafenib could be an alternative for patients who are ineligible for anti-angiogenic therapy.

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Publication Details

Journal
Annals of Medicine
Published
2026-02-23
DOI
https://doi.org/10.1080/07853890.2026.2624215
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Molecular targeted therapy in combination with chemotherapy for the treatment of platinum-resistant/refractory ovarian cancer (PROC): a systematic review and network meta-analysis

Tianshu Ying, E. Shaolong, Huanchun Ying
Annals of Medicine
Ovarian cancer diagnosis and treatment
article

Molecular targeted therapy in combination with chemotherapy for the treatment of platinum-resistant/refractory ovarian cancer (PROC): a systematic review and network meta-analysis

Tianshu Ying, E. Shaolong, Huanchun Ying
article en

Abstract

Bevacizumab-based combinations demonstrate consistent benefits across multiple regimens for PROC. Paclitaxel + bevacizumab emerges as the optimal balance of efficacy and safety. Topotecan + sorafenib could be an alternative for patients who are ineligible for anti-angiogenic therapy.

Annals of MedicineVol. 58(1)
China Medical University (CN)
Good health and well-being
Openalex Percentile: Top 42%
Ovarian cancer diagnosis and treatment
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