Resveratrol‒loaded self‒assembled tetrahedral framework nucleic acids reshape the epileptic microenvironment by regulating oxidative stress and neuroinflammation via the SIRT3/SOD2 pathway

This study presents a novel nanotherapeutic strategy that integrates microenvironment remodeling with neural repair. By leveraging the specific brain‒targeting capability of tFNAs and the synergistic antioxidant properties of the core‒shell structure, R‒tFNAs@PB represent a promising approach for treating refractory epilepsy through the precise regulation of the oxidative stress‒neuroinflammation axis via the SIRT3/SOD2 pathway.