Attenuation of the CpG island methylator phenotype and lack of WNT signalling activation restrains Kras mutant intestinal neoplasia
Kras mutation can induce serrated neoplasia, but with significantly greater latency period and lower penetrance compared to Braf. Kras-mutant neoplasms display an attenuated CIMP-like phenotype, rarely developing aberrant WNT signalling. These data refine our understanding of MAPK-induced intestinal neoplasia.
Authors
- Alexandra Kane (ORCID: https://orcid.org/0000-0002-3414-8455)
- Simon Manuel Tria (ORCID: https://orcid.org/0000-0002-0562-7916)
- Jennifer Borowsky (ORCID: https://orcid.org/0000-0003-3957-1364)
- Lochlan J. Fennell
- Lu Chai
- Barbara Leggett
- Vicki Whitehall
- Catherine Bond
- Sarron Randall-Demllo
- Diane McKeone
- Cheng Liu
Institutions
- Griffith University (AU)
- Queensland Health (AU)
- The University of Queensland (AU)
- University of the Sunshine Coast (AU)
- QIMR Berghofer Medical Research Institute (AU)
- Royal Brisbane and Women's Hospital (AU)
- Discovery Institute (US)
- Envoi Specialist Pathologists (AU)
- Sunshine Coast University Hospital (AU)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1038/s41416-025-03271-3
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00