Location patterns and longitudinal progression of white matter hyperintensities
We presented a robust and scalable framework for spatial WMH phenotyping. We discussed clinical and prognostic implications of the spatial subtypes beyond total lesion burden. Our findings supported the value of WMH spatial characterisation in stratifying risk that may help guide personalised approaches to managing CSVD.
Authors
- N. Chaturvedi
- Xin Zhao (ORCID: https://orcid.org/0000-0003-3482-4481)
- Thomas M. Brown
- David M Cash
- Frederik Barkhof
- Jonathan Schott
- Carole H Sudre
- Andrew Wong
- Josephine Barnes
- Ian B Malone
- Alun D Hughes
- Alzheimer’s Disease Neuroimaging Initiative
Institutions
- King's College London (GB)
- Hawassa University (ET)
- UK Dementia Research Institute (GB)
- MRC Unit for Lifelong Health and Ageing (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-23
- DOI
- https://doi.org/10.64898/2026.02.20.26346709
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Avid Radiopharmaceuticals
- Canadian Institutes of Health Research