Glycine receptors in circulating white blood cells regulated by neuroinflammation
Together, these findings define a brain-glycinergic signaling-blood axis that maintains homeostatic protectivity. GlyR subunits, particularly GlyRα1 and α3, represent a neuropathology-induced modulation of GlyR signaling in peripheral immune cells.
Authors
- Brianna Rodriguez (ORCID: https://orcid.org/0000-0003-2489-4275)
- Jonathan Lavezo (ORCID: https://orcid.org/0000-0002-4329-3136)
- Gustavo Rodríguez (ORCID: https://orcid.org/0000-0003-2781-5034)
- Vikram Thakur (ORCID: https://orcid.org/0000-0003-1754-762X)
- Huanyu Dou (ORCID: https://orcid.org/0000-0001-8777-8963)
- Osarenoma Evbuomwan
- Alexandra Chavez
- Lizbeth Lopez
- Yathip Mindy Chokpapone
- Ingrid Carrizales
- Camila Guerrero
- Rakshak Mishra
Institutions
- Texas Tech University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fimmu.2026.1749275
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Prevention and Research Institute of Texas
- Texas Tech University
- Texas Tech University Health Sciences Center
- National Institutes of Health