New approaches to uncover COPD pathobiology and develop therapies
Chronic obstructive pulmonary disease (COPD) was the third leading cause of global mortality in 2011 but receives limited attention and research funding. This Review describes the current knowledge on COPD risk factors, including genetic and epigenetic determinants and their interactions with the microbiome and environmental exposures. Preclinical models are being refined and single-cell transcriptomic, metabolomic, and proteomic technologies are being implemented to investigate the molecular mechanisms of disease progression. Patient cohorts to define biomarkers of early disease and the latest approaches to diagnose pre-COPD are essential to accelerate the development of novel and effective therapeutic interventions and translate new findings into clinical trials. This Review is a summary of topics covered by a symposium organized by the COPD-iNET consortium, an international network of researchers who have established a platform that facilitates collaboration of this multidisciplinary group of preclinical, translational, and clinical researchers.
Authors
- Dave A. Lagowala
- Hasan Hüseyin Bayram (ORCID: https://orcid.org/0000-0003-3424-8613)
- M Lehmann
- Carter Swaby
- Linto Antony (ORCID: https://orcid.org/0000-0002-8762-3299)
- Thomas M. Conlon (ORCID: https://orcid.org/0000-0002-4316-6612)
- Kambez H. Benam (ORCID: https://orcid.org/0000-0001-9117-3959)
- Enid Neptune (ORCID: https://orcid.org/0000-0002-9635-1272)
- Yohannes Tesfaigzi (ORCID: https://orcid.org/0000-0002-3997-5839)
- Dinh Bui (ORCID: https://orcid.org/0000-0002-4388-784X)
- K. Bankoti
- Beata Kośmider (ORCID: https://orcid.org/0000-0001-7421-5424)
- Renata Z. Jurkowska (ORCID: https://orcid.org/0000-0002-4507-2222)
- Karim Bahmed (ORCID: https://orcid.org/0000-0001-9854-5452)
- Z.H. Negasi (ORCID: https://orcid.org/0000-0002-4028-4269)
- Roxana Wasnick (ORCID: https://orcid.org/0000-0003-1114-7799)
- Purushothama Rao Tata (ORCID: https://orcid.org/0000-0003-4837-0337)
- F. La Rosa
- AÖ Yildirim (ORCID: https://orcid.org/0000-0001-6340-3884)
- Maor Sauler
- Yeşim Vural
- Michael H. Cho
- Venkataramana Sidhaye
- S. Vamsee Raju
- Francesca Polverino
- George Washko
- Peter Castaldi
- Edwin K. Silverman
- Bartolome Celli
- Ramon C. Sun
Institutions
- Brigham and Women's Hospital (US)
- Koç University (TR)
- Harvard University (US)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Duke University (US)
- Baylor College of Medicine (US)
- Johns Hopkins Medicine (US)
- University of Alabama at Birmingham (US)
- Yale University (US)
- University of Florida (US)
- Massachusetts General Hospital (US)
- Institut thématique Immunologie, inflammation, infectiologie et microbiologie (FR)
- Institute for Research in Biomedicine (ES)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Inflammation Research Foundation (US)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- Cellular Research (United States) (US)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Victoria University (AU)
- Cardiff University (GB)
- Ludwig-Maximilians-Universität München (DE)
- Temple University (US)
Publication Details
- Journal
- JCI Insight
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1172/jci.insight.199693
- Primary Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- AstraZeneca
- National Institutes of Health