Memory Regulatory T Cells as a Biomarker of Early Type 1 Diabetes
There are more memory regulatory T cells (Tregs) in individuals with type 1 diabetes (T1D) and siblings than in healthy control (HC) individuals. Individuals with T1D and their siblings share an immunological profile, with siblings displaying an intermediate phenotype that overlaps with both T1D and HC individuals. Memory Tregs increased with age in HC individuals and siblings but not in individuals with T1D. Diabetic ketoacidosis status had no impact on immune cell populations in patients with T1D.
Authors
- Erica Pozzi (ORCID: https://orcid.org/0000-0003-0937-8010)
- Giuseppe Cappellano (ORCID: https://orcid.org/0000-0001-5193-4688)
- Davide Raineri (ORCID: https://orcid.org/0000-0003-3327-6305)
- Flavia Prodam (ORCID: https://orcid.org/0000-0001-9660-5335)
- Silvia Savastio (ORCID: https://orcid.org/0000-0002-1816-1895)
- Ivana Rabbone
- Camilla Barbero-Mazzucca
- Annalisa Chiocchetti
- Lorenza Scotti
- Simonetta Bellone
Institutions
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- Piedmont University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2026-02-23
- DOI
- https://doi.org/10.2337/db25-0161
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dipartimenti di Eccellenza
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi del Piemonte Orientale