Global, regional, and national burden of non-rheumatic calcific aortic valve disease, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Global NRCAVD burden remains unequal, particularly in high-SDI regions where mortality rates are disproportionately high. Addressing widening inequalities requires sex-specific interventions for aging populations, expanded access to cost-effective valvular therapies, and strengthened health systems in underserved regions. Multinational collaboration to standardize NRCAVD surveillance and share best practices in lifecycle management is imperative to achieve health equity in an aging world.