Sustainable and Scalable Redesign of PS-750-M Synthesis While Retaining Micellar Catalytic Efficiency

An efficient, two-step synthetic route for PS-750-M has been developed, offering significant improvements in terms of sustainability, scalability, and operational simplicity compared to the conventional four-step process. The new methodology eliminates hazardous reagents, toxic solvents, and chromatography, while enabling solvent recovery and catalyst reuse. Quantitative green metrics reveal dramatic reductions in environmental impact, with E-factor and Process Mass Intensity (PMI) decreasing by over 90% and 85%, respectively. Importantly, PS-750-M, synthesized via this greener route, retains its micellar catalytic efficiency tested on a variety of transformations, including palladium-catalyzed C-C couplings, Buchwald-Hartwig aminations, biaryl ketone formation, and rapid amide couplings. These results support the industrial viability of the redesigned process and its alignment with the principles of green chemistry, potentially facilitating the large-scale adoption of this approach in pharmaceutical and fine chemical manufacturing.