Shared Neurocardiac Pathways Linking Atrial Fibrillation and Depression: A UK Biobank Analysis
AF and MDD demonstrate bidirectional associations characterized by shared inflammatory, cardiovascular, and neural correlates, alongside distinct and non-additive alterations within central autonomic network circuits. These findings support a systems-level neurocardiac framework linking cardiac and psychiatric disease and highlight the importance of integrated approaches to risk assessment and multidisciplinary management in patients with AF-MDD comorbidity.
Authors
- Aleksandr Talishinsky (ORCID: https://orcid.org/0000-0002-7225-2130)
- Sahib S. Khalsa (ORCID: https://orcid.org/0000-0003-2124-8585)
- Masaya Misaki (ORCID: https://orcid.org/0000-0002-6829-4311)
- Navid Hakimi
- W. Burt Thompson (ORCID: https://orcid.org/0000-0001-6078-8846)
- Olujimi A. Ajijola (ORCID: https://orcid.org/0000-0001-6197-7593)
- Chun Chieh Fan
- Jonas Steinhauser
- Martin P. Paulus
- Charles Verdonk
Institutions
- University of California, Los Angeles (US)
- Laboratoire d'Informatique Algorithmique: Fondements et Applications (FR)
- Neurobehavioral Systems (US)
- Unit of Functional and Adaptive Biology (FR)
- Laureate Institute for Brain Research (US)
- Technische Universität Dresden (DE)
- University of Tulsa (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-23
- DOI
- https://doi.org/10.64898/2026.02.21.26346796
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- William K. Warren Foundation
- Boston Scientific Corporation
- Fédération pour la Recherche sur le Cerveau
- Fondation des Gueules Cassées
- National Institutes of Health
- Laureate Institute for Brain Research, University of Tulsa
- National Institute of Mental Health
- National Institute of General Medical Sciences
- Biosense Webster
- Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles