Fungal Sinusitis Masquerading as Trigeminal Neuralgia in an Immunocompetent Patient: A Case Report

Previous cases of trigeminal neuralgia (TN) caused by fungal sinusitis have been reported, but mainly in immunocompromised patients. We present a case of fungal sinusitis masquerading as trigeminal neuralgia in an immunocompetent patient and discuss the potential implications of these two diseases. The patient is a 59-year-old male who presented with a four-year duration of left facial pain. He had been diagnosed and treated for trigeminal neuralgia by a pain specialist but was subsequently referred to ENT after a MRI of the brain showed left maxillary sinusitis. Nasoendoscopy findings and a CT scan of the paranasal sinuses were concordant with left maxillary sinusitis. The patient underwent left functional endoscopic sinus surgery and recovered uneventfully. Our study shows that even in immunocompetent patients who present with non-resolving or worsening facial pain resembling the original diagnosis of TN, clinicians should remain vigilant for the possibility of alternative underlying pathologies including fungal sinusitis.

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Publication Details

Journal
Sinusitis
Published
2026-02-23
DOI
https://doi.org/10.3390/sinusitis10010004
Primary Topic
Sinusitis and nasal conditions
Type
article
Field-Weighted Citation Impact
0.00
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article

Fungal Sinusitis Masquerading as Trigeminal Neuralgia in an Immunocompetent Patient: A Case Report

Owen Tsung Wen Ho, Kok Yuen Ho, Alex Chengyao Tham
Sinusitis
Sinusitis and nasal conditions
article

Fungal Sinusitis Masquerading as Trigeminal Neuralgia in an Immunocompetent Patient: A Case Report

Owen Tsung Wen Ho, Kok Yuen Ho, Alex Chengyao Tham
article en

Abstract

Previous cases of trigeminal neuralgia (TN) caused by fungal sinusitis have been reported, but mainly in immunocompromised patients. We present a case of fungal sinusitis masquerading as trigeminal neuralgia in an immunocompetent patient and discuss the potential implications of these two diseases. The patient is a 59-year-old male who presented with a four-year duration of left facial pain. He had been diagnosed and treated for trigeminal neuralgia by a pain specialist but was subsequently referred to ENT after a MRI of the brain showed left maxillary sinusitis. Nasoendoscopy findings and a CT scan of the paranasal sinuses were concordant with left maxillary sinusitis. The patient underwent left functional endoscopic sinus surgery and recovered uneventfully. Our study shows that even in immunocompetent patients who present with non-resolving or worsening facial pain resembling the original diagnosis of TN, clinicians should remain vigilant for the possibility of alternative underlying pathologies including fungal sinusitis.

SinusitisVol. 10(1)
Mount Elizabeth Hospital (SG), Tan Tock Seng Hospital (SG), Mount Alvernia Hospital (GB), Dermatology Specialists (US)
Good health and well-being
Openalex Percentile: Top 46%
Sinusitis and nasal conditions
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