Targeting the NSUN2–DHODH axis reverses ferroptosis resistance and oxaliplatin resistance in colorectal cancer
These findings identify an NSUN2-DHODH epitranscriptomic axis that promotes CRC progression and OXA resistance by limiting ferroptosis, supporting NSUN2-targeting and ferroptosis-inducing strategies to improve chemotherapy response.
Authors
- Chang Gao (ORCID: https://orcid.org/0000-0001-7825-0024)
- Junxiao Shen (ORCID: https://orcid.org/0000-0002-1552-4689)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-1116-4559)
- Zeng Wang (ORCID: https://orcid.org/0009-0005-4044-5885)
- Tangye Zeng
- Biao Sheng
- Junliang Li
- Chong Shen
- Jieyi Shen
- Junyi Zhang
- Jiaojiao Wang
Institutions
- Zhejiang International Studies University (CN)
- Chinese Academy of Sciences (CN)
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Party School (CN)
- Zhejiang Cancer Hospital (CN)
- Ministry of Education (ET)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fphar.2026.1739981
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province