Gray-white matter covarying impairment in the anterior cingulate cortex revealed by multimodal meta-analysis of post-stroke cognitive impairment

This study applied SDM-PSI multimodal meta-analysis to delineate characteristic neurostructural damage patterns in PSCI. Key findings encompass gray matter atrophy within frontotemporal cognitive hubs (FWE-corrected). Additionally, exploratory analyses suggested potential covarying GM-WM pathology in the left anterior cingulate/paracingulate gyri (BA 11/25; <i>p</i> = 0.043, uncorrected). These findings elucidate PSCI pathogenesis and suggest potential anatomical targets for future research.