Defining alteration in bone marrow mesenchymal stem cells (MSC) from acute myeloid leukemia and exploring cultured MSC-conditioned media as a novel anti-leukemia therapy agent
Summarizing, the leukemic blasts and AML-MSC in the BM microenvironment interact differentially in cell-cell contact compared to only soluble factors. Further, our study has provided innovative leads that PD-MSC-CM effectively abrogates leukemia tumor growth, enhances chemosensitivity and can be developed further as an immunomodulatory novel "off-the-shelf" therapeutic agent for leukemia.
Authors
- Sumeet Mirgh (ORCID: https://orcid.org/0000-0003-0642-2207)
- Poonam Gera (ORCID: https://orcid.org/0000-0001-7709-1594)
- Elveera Saldanha (ORCID: https://orcid.org/0000-0002-4748-8344)
- Shubhada Chiplunkar (ORCID: https://orcid.org/0000-0003-3421-0076)
- Navin Khattry (ORCID: https://orcid.org/0000-0001-5708-6472)
- Manasi Nagare
- Sachin Punatar (ORCID: https://orcid.org/0000-0002-7461-4772)
- S Epari
- Jyoti Kode (ORCID: https://orcid.org/0000-0001-6907-2449)
- Bhausaheb Bagal (ORCID: https://orcid.org/0000-0001-9754-0182)
- Anant Gokarn (ORCID: https://orcid.org/0000-0002-8725-8375)
- Tanuja M. Shet (ORCID: https://orcid.org/0000-0001-9294-9704)
- Trupti Pradhan (ORCID: https://orcid.org/0000-0001-5491-2070)
- Madan Barkume
- Jitendra Gawde
- Rohit Kumar Verma
- Shweta Shirsat
- Hasmukh Jain
- Manju Sengar
- Monalisa Sahoo
- Caroline Mathen
Institutions
- Homi Bhabha National Institute (IN)
- Bharat Heavy Electricals (India) (IN)
- Tata Memorial Hospital (IN)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1007/s00262-025-04262-2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Advanced Centre for Treatment, Research and Education in Cancer