Total flavonoids of <i>Abelmoschus manihot</i> (L.) medic attenuate early renal injury in diabetic kidney disease by modulating the LINC00665/miR-379-5p axis
<b>Conclusions:</b> The LINC00665/miR-379-5p axis contributes to DKD pathogenesis. TFA exerts therapeutic effects against early renal injury in DKD by suppressing LINC00665 and consequently upregulating miR-379-5p activity.
Authors
- Jianmin Wu (ORCID: https://orcid.org/0000-0002-0999-9194)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Y. Zeng
- Nan Li
- Yaohui Fang
- Harvest F Gu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Qilu University of Technology (CN)
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1080/13880209.2026.2630430
- Primary Topic
- Botanical Studies and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00