In vitro and ex vivo cutaneous bioavailability and biotransformation of silymarin and its constituents
In HSE, the metabolic transformation of SM's components and its pure polyphenols was more extensive, as skin fragments are a more complex cellular and metabolically active system. Human skin ex vivo seems to be a useful tool for studying compounds biotransformation at topical application.
Authors
- Pavel Kosina (ORCID: https://orcid.org/0000-0003-1991-1990)
- Jiří Hanyk (ORCID: https://orcid.org/0000-0001-8201-0365)
- Barbora Papoušková (ORCID: https://orcid.org/0000-0001-5421-3763)
- Kateřina Valentová (ORCID: https://orcid.org/0000-0002-7714-5350)
- Alena Ryšavá (ORCID: https://orcid.org/0000-0001-8218-3987)
- Jitka Vostálová (ORCID: https://orcid.org/0000-0003-0948-0891)
- Alena Rajnochová Svobodová (ORCID: https://orcid.org/0000-0002-7868-3169)
- Bohumil Zálešák
Publication Details
- Journal
- Skin Pharmacology and Physiology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1159/000550859
- Primary Topic
- Silymarin and Mushroom Poisoning
- Type
- article
- Field-Weighted Citation Impact
- 0.00