Cortical Bone Defects at MCP and Wrist Joints in Healthy Individuals assessed by HR-pQCT

Numerous bone erosions were identified in the MCP and wrist joints of healthy individuals. Relatively well-defined erosions measuring ≥0.5 mm3 were frequently observed in specific carpal bones, particularly the capitate and lunate. Additionally, erosions smaller than 0.5 mm3 showed a positive correlation with age, suggesting that numerous small cortical bone defects may represent age-related physiological changes. These findings provide important context when interpreting erosive changes associated with joint diseases in clinical practice.