Von Willebrand Factor and ADAMTS13 in Relation to Major Adverse Limb Events in Peripheral Artery Disease
Contrary to our original hypothesis, lower baseline VWF levels and VWF/ADAMTS13 ratios were associated with subsequent MALE in this high-risk PAD cohort, which may reflect increased VWF consumption in severe, diffuse atherosclerosis. This study contributes to the limited literature on VWF and ADAMTS13 in PAD in relation to MALE, as previous research has largely focused on major adverse cardiovascular events. Larger studies in patients with similar risk profiles are required to validate these findings.
Authors
- Mohammad Qadura (ORCID: https://orcid.org/0000-0003-0893-9920)
- Vinai Bhagirath (ORCID: https://orcid.org/0000-0001-6600-714X)
- Colin A. Kretz (ORCID: https://orcid.org/0000-0001-7979-7603)
- Peter Andrisani (ORCID: https://orcid.org/0009-0001-5796-958X)
- Noa Agid (ORCID: https://orcid.org/0009-0007-1358-0912)
- Hamzah Khan
Institutions
- St. Michael's Hospital (CA)
- Thrombosis and Atherosclerosis Research Institute (CA)
- Hamilton Health Sciences (CA)
- McMaster University (CA)
Publication Details
- Journal
- Vascular Specialist International
- Published
- 2026-02-23
- DOI
- https://doi.org/10.5758/vsi.250103
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Canadian Institutes of Health Research