Multimodal MRI reveals structural and functional alterations in isolated cervical dystonia: associations with motor severity and affective symptoms
These findings support ICD as a network disorder involving both motor and cognitive-affective circuits. Structural alterations in the PCL and MTG and their connectivity patterns may underlie motor dysfunction and nonmotor symptoms such as anxiety. Multimodal neuroimaging biomarkers may help guide targeted therapeutic interventions and improve clinical outcomes in ICD.
Authors
- Qulian Guo (ORCID: https://orcid.org/0000-0002-5636-8491)
- Yaru Luo (ORCID: https://orcid.org/0009-0009-2912-1352)
- Naixuan Du (ORCID: https://orcid.org/0009-0004-3446-9349)
- Jinyang Li
- Jihua Liu
- Jiongyue Yun
- Zhongyuan Xia
Institutions
- Wuhan University (CN)
- National Clinical Research (US)
- First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (CN)
- Renmin Hospital of Wuhan University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fneur.2026.1771144
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00