Innate Immunity Trained in the Protective Response of Vaccine Candidates Against Intracellular Pathogens

Trained innate immunity enhances the protective effect of inactivated experimental vaccines against <i>B. ovis</i> and <i>L. monocytogenes</i>, while exerting a detrimental influence on the efficacy of a live attenuated <i>B. ovis</i> vaccine model.

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Publication Details

Journal
Vaccines
Published
2026-02-23
DOI
https://doi.org/10.3390/vaccines14020197
Primary Topic
Immune responses and vaccinations
Type
article
Field-Weighted Citation Impact
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article

Innate Immunity Trained in the Protective Response of Vaccine Candidates Against Intracellular Pathogens

A. M. F., Marcella Pecora Milazzotto, Tatiane A. Paixão, Laice A. Silva et al.
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Innate Immunity Trained in the Protective Response of Vaccine Candidates Against Intracellular Pathogens

A. M. F., Marcella Pecora Milazzotto, Tatiane A. Paixão, Laice A. Silva, Robson S. Barducci, Camila G. Almeida, Jefferson B. S. Oliveira, Renato L. Santos, Monique F. S. Sousa, Humberto M. Brandão
article en

Abstract

Trained innate immunity enhances the protective effect of inactivated experimental vaccines against <i>B. ovis</i> and <i>L. monocytogenes</i>, while exerting a detrimental influence on the efficacy of a live attenuated <i>B. ovis</i> vaccine model.

VaccinesVol. 14(2)
Universidade Federal de Minas Gerais (BR), Brazilian Agricultural Research Corporation (BR), Fundação de Estudo e Pesquisa em Medicina Veterinária e Zootecnia (BR), Associação Paulista para o Desenvolvimento da Medicina (BR), Universidade Federal do ABC (BR)
Good health and well-being
Openalex Percentile: Top 45%
Immune responses and vaccinations
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