Oncolytic zika virus therapy leverages CCR2+ monocytes to boost anti-glioblastoma T cell responses
ZIKV-driven activation and recruitment of CCR2+ monocytes supports robust anti-tumor CD8+ T cell responses by enhancing cytotoxicity and limiting exhaustion. These findings highlight the previously unappreciated therapeutic potential of modulating monocyte-T cell crosstalk to overcome immune suppression in GBM.
Authors
- Ashwani Kesarwani (ORCID: https://orcid.org/0000-0002-4008-6289)
- Amanda De Andrade Costa (ORCID: https://orcid.org/0009-0006-2834-988X)
- Jonah C. Daneshmand (ORCID: https://orcid.org/0000-0002-7101-7542)
- Sharmila Nair
- Akshitkumar M. Mistry (ORCID: https://orcid.org/0000-0002-7918-5153)
- Milan Chheda
- Michael S Diamond
- Hammad Ur Rehman
- Kevin S Cashman
- Matthias Mack
Institutions
- University of Louisville (US)
- Washington University in St. Louis (US)
- University Hospital Regensburg (DE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-02-21
- DOI
- https://doi.org/10.1093/neuonc/noag037
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00