Changes in absolute coronary blood flow and myocardial resistance after percutaneous coronary intervention
PCI significantly reduces epicardial resistance, leading to a pronounced increase in hyperaemic flow, which can be predicted by FFR. Resting Q remained unchanged because of compensatory increases in microvascular resistance, providing direct evidence of coronary flow autoregulation in humans. The MRR was unaffected by PCI, confirming its specificity as an index of microvascular function.
Authors
- Jason Chai (ORCID: https://orcid.org/0000-0002-7398-9564)
- Rafail A. Kotronias (ORCID: https://orcid.org/0000-0001-8132-6130)
- Thabo Mahendiran
- Grigoris V. Karamasis
- Sarosh Khan
- John R. Davies
- Giovanni Luigi De Maria
- Bernard De Bruyne
- Adrian P. Banning
- Thomas R. Keeble
- Federico Marin
- Carlos Collet
- Christopher M. Cook
- on behalf of the OxAMI Study Investigators
- Jason Walsh
- Keith Channon
- Samer Fawaz
Institutions
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Onze Lieve Vrouwziekenhuis Hospital (BE)
- Essex Cardiothoracic Centre (GB)
- Basildon Hospital (GB)
- Flanders Environment Agency (BE)
- Anglia Ruskin University (GB)
- University of Lausanne (CH)
Publication Details
- Journal
- EuroIntervention
- Published
- 2026-02-23
- DOI
- https://doi.org/10.4244/eij-d-25-00784
- Citations
- 1
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 31.92