The Preservation of Muscle Mitochondrial Machinery During Hypometabolic Hibernation in Scandinavian Brown Bears ( <scp> <i>Ursus arctos</i> </scp> )
These findings highlight a temperature-sensitive, multifaceted strategy that preserves mitochondrial energetics during prolonged inactivity, despite reduced mitochondrial density. The selective maintenance of electron flow and fuel flexibility offers novel insights for mitigating muscle wasting in sedentary or immobilized humans.
Authors
- Isabelle Chery
- Fabrice Bertile
- Laura Cussonneau (ORCID: https://orcid.org/0000-0002-3017-2685)
- Étienne Lefai (ORCID: https://orcid.org/0000-0002-3042-7801)
- Audrey Bergouignan (ORCID: https://orcid.org/0000-0002-1266-5144)
- John Noone (ORCID: https://orcid.org/0000-0002-5733-4816)
- Alina L. Evans (ORCID: https://orcid.org/0000-0003-0513-4887)
- Charlotte Brun (ORCID: https://orcid.org/0000-0001-8842-8420)
- Jonas Kindberg
- Donal O'Gorman
- Cecile Coudy-Gandilhon
- Guillemette Gauquelin-Koch
- Jon Martin Arnemo
- Alexandre Geffroy
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Limerick (IE)
- Centre National d'Études Spatiales (FR)
- Swedish University of Agricultural Sciences (SE)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- University of Inland Norway (NO)
- Centre de Recherche en Nutrition Humaine d'Auvergne (FR)
- Norwegian Institute for Nature Research (NO)
- French Clinical Research Infrastructure Network (FR)
- Dublin City University (IE)
- University of Colorado Anschutz Medical Campus (US)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1111/apha.70177
- Primary Topic
- Bat Biology and Ecology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Strong
- Agence Nationale de la Recherche
- Centre National d’Etudes Spatiales
- Université de Strasbourg
- Naturvårdsverket
- Centre National de la Recherche Scientifique
- Miljødirektoratet