Imaging vascular characteristics and glycolytic metabolism of glioblastoma in a chick embryo model using 1H MRI and [18F]FDG-PET
The CAM model provides a versatile platform for investigating GBM vascularisation and metabolism. Hypoxic conditioning amplifies transcriptional and vascular changes to the CAM. Although both [<sup>18</sup>F]FDG uptake and lactate were measurable, no significant correlation between the two was observed, potentially reflecting variability in tumour engraftment, vascular delivery of [<sup>18</sup>F]FDG, and microenvironmental influences on lactate accumulation.
Authors
- Harish Poptani (ORCID: https://orcid.org/0000-0002-0593-3235)
- Stephen Pickup (ORCID: https://orcid.org/0000-0002-7016-8648)
- Sonia Rocha
- Michael Batie (ORCID: https://orcid.org/0000-0002-7508-6641)
- Judy M. Coulson (ORCID: https://orcid.org/0000-0003-2191-2001)
- Mohesh Moothanchery
- Rasheed Zakaria
- Elisabeth Non Gash
- Jan Schulze
- Sarah E. Barnett
- Mahon L. Maguire
- Ian Scott
Institutions
- University of Liverpool (GB)
- Walton Centre (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1007/s11307-026-02084-x
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- North West Cancer Research