Integrative Transcriptomic and Proteomic Profiling Defines Secretory and Immune Related Subtypes in Pancreatic Ductal Adenocarcinoma
This integrative multiomics analysis delineates three biologically and clinically distinct PDAC subtypes. The results highlight metabolic and functional diversity underlying tumor heterogeneity, offering new insights for precision stratification and the development of targeted therapeutic strategies.
Authors
- Haoteng Luo
- Shizhao Lin
- Xiangqing Yao
- Shangeng Weng (ORCID: https://orcid.org/0000-0001-8802-6616)
- Tianhong Teng (ORCID: https://orcid.org/0000-0002-2393-3001)
- Kun Ke
- Han Shi
Institutions
- Fujian Medical University (CN)
- National Hospital (IN)
- City University (BD)
- First Affiliated Hospital of Fujian Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Journal of Proteome Research
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1021/acs.jproteome.5c01146
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00