Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration
GzmB is a key mediator of mast cell-induced CNV. Targeting GzmB, either directly or through mast cell stabilization, offers a promising strategy for reducing angiogenesis in a condition such as wet AMD.
Authors
- David J. Granville (ORCID: https://orcid.org/0000-0001-6985-2816)
- Jeanne Xi
- Amir Hosseini
- Hyung-Suk Yoo (ORCID: https://orcid.org/0000-0001-6750-165X)
- Harshini Chakravarthy (ORCID: https://orcid.org/0000-0002-2744-0642)
- Zhengdong Ai (ORCID: https://orcid.org/0009-0000-7726-0562)
- Khola Bilal
- Chuan-Hui Kuo
- Isa Samad
- Wania Khan
- Neilan Tan
- Joanne A. Matsubara
- Manjosh Uppal
- Gurmohit Gill
Institutions
- University of British Columbia Hospital (CA)
- Vancouver Coastal Health (CA)
- University of British Columbia (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fimmu.2026.1710965
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada