Analytical interpretation of hemodynamic data in patients with intracardiac shunts: Role of mathematical modeling
This model analytically illustrates that shunt through an ASD is minimally affected by PVRs. The marginal change of pulmonary flow produced by large variations of PVR appeared mediated by changes in right ventricular elastance. The effect of pulmonary vasodilators in patients with ASD can be concealed or enhanced by increased stiffness of the right or left ventricle, respectively.
Authors
- Stiljan Hoxha (ORCID: https://orcid.org/0000-0003-1984-6172)
- Giulio Valenti (ORCID: https://orcid.org/0000-0002-8002-6133)
- A. Quarteroni
- Pier Paolo Bassareo (ORCID: https://orcid.org/0000-0002-8374-0260)
- Andrea Tonini (ORCID: https://orcid.org/0009-0004-9290-7116)
- Paolo Ferrero
- Luca Dedè
- Konstantinos Dimopoulos
Institutions
- University College Dublin (IE)
- University of Verona (IT)
- Royal Brompton Hospital (GB)
- Politecnico di Milano (IT)
Publication Details
- Journal
- International Journal of Cardiology Congenital Heart Disease
- Published
- 2026-02-22
- DOI
- https://doi.org/10.1016/j.ijcchd.2026.100662
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Istituto Nazionale di Alta Matematica "Francesco Severi"
- Gruppo Nazionale per il Calcolo Scientifico