Deep learning-derived quantitative interstitial abnormalities in early rheumatoid arthritis and healthy controls: A multicenter, prospective cross-sectional study
Participants with early RA had less normal lung and more interstitial abnormalities on a deep learning-derived QCT measure than healthy controls. These results suggest that loss of normal lung is already present in early RA and emphasizes the urgent need for strategies to preserve lung health in RA.
Authors
- Erica Mulcaire-Jones
- X. Wang
- Gregory C McDermott (ORCID: https://orcid.org/0000-0002-9750-5448)
- Neda Kortam
- G. Qian
- Marcy B. Bolster (ORCID: https://orcid.org/0000-0002-5413-9345)
- Kathleen M.M. Vanni (ORCID: https://orcid.org/0000-0003-0839-9661)
- Tina Mahajan
- E. Kowalski
- Pierre‐Antoine Juge (ORCID: https://orcid.org/0000-0002-3766-9600)
- Kevin T. Mueller
- Paul F. Dellaripa
- George R Washko
- Staci M. Gagne
- Alene A. Saavedra
- Madison Negron
- Liya Sisay Getachew
- Madeleine Beaule
- Caleb Bolden
- Misti L. Paudel
- Ritu Gill
- Michael H. Cho
- YIng Qi
- Jeffrey A. Sparks
- Bryant R. England
- Kevin D. Deane
- Suzanne Byrne
- Natalie A. Davis
- Lauren A. O'Keeffe
- Edwin K. Silverman
- Dinesh Khanna
- Tracy J. Doyle
- Raul San Jose Estepar
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Inserm (FR)
- Université Paris Cité (FR)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Massachusetts General Hospital (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- VA Nebraska Western Iowa Health Care System (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-22
- DOI
- https://doi.org/10.64898/2026.02.20.26346723
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- George Gund Foundation
- Amgen
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Rheumatology Research Foundation
- University of Nebraska Medical Center
- COPD Foundation
- Sunovion
- ReCor Medical
- Argenx
- Swedish Orphan Biovitrum
- National Institutes of Health
- Genentech
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- Janssen Pharmaceuticals