Genetic Prediction of Circulating Lipoprotein(a) Levels in Diverse Populations
A haplotype-based genetic model effectively identified individuals with elevated Lp(a) levels across diverse populations, with potential utility for opportunistic screening among cohorts where genotype data is available, but Lp(a) testing rates are low.
Authors
- Girish Nadkarni
- Archna Bajaj
- Renae Judy
- Ron Do
- Margaret Sunitha Selvaraj
- Michael Levin
- Ha My Vy
- Michael C. Honigberg
Institutions
- Broad Institute (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- Harvard University (US)
- Cardiovascular Institute of the South (US)
- Translational Therapeutics (United States) (US)
- Philadelphia VA Medical Center (US)
- Center for Genomic Science (IT)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-22
- DOI
- https://doi.org/10.64898/2026.02.20.26346738
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- U.S. Department of Veterans Affairs
- University of Pennsylvania
- Regeneron Pharmaceuticals
- Georgia Clinical and Translational Science Alliance
- University of Pennsylvania Health System
- National Institutes of Health
- Perelman School of Medicine, University of Pennsylvania
- National Center for Advancing Translational Sciences