Efficacy and safety of modafinil in post-stroke fatigue: a systematic review and meta-analysis
Current evidence does not support modafinil as a routine treatment for PSF. Its effect on mental fatigue is of very low certainty, limiting the strength of this finding. Clinicians should interpret these findings cautiously, and use modafinil only on a case-by-case basis. Larger, high-quality trials with standardized fatigue measures are needed to identify responders and clarify its clinical role.
Authors
- Mariana Letícia de Bastos Maximiano (ORCID: https://orcid.org/0009-0005-8359-6763)
- Marcos De Oliveira Machado
- Leonora Ramlow Leodoro da Silva
- João Antônio Ramlow Leodoro da Silva
- Yasmin Picanço Silva (ORCID: https://orcid.org/0009-0003-5728-4964)
- Giovanna Cristina Gonçalves Camacho
- João Victor Pereira Gonzalez
- Gabriel Caruso Novaes Tudella
- Iago Nathan Simon Petry
- Luis Gustavo Biondi Soares
Institutions
- Escola Bahiana de Medicina e Saúde Pública (BR)
- University of Iceland (IS)
- Universidade Federal de Santa Maria (BR)
- Universidade do Sul de Santa Catarina (BR)
- Santa Casa de Montes Claros - Irmandade Nossa Senhora das Mercês
Publication Details
- Journal
- Neurological Research
- Published
- 2026-02-22
- DOI
- https://doi.org/10.1080/01616412.2026.2631155
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 0.00